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Open Access Publications from the University of California

PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis

  • Author(s): Collisson, Eric
  • Ng, S
  • Collisson, EA
  • Sokolov, A
  • Goldstein, T
  • onzalez-Perez, A
  • Lopez-Bigas, N
  • Benz, C
  • Haussler, D
  • Stuart, JM
  • et al.

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Motivation: A current challenge in understanding cancer processes is to pinpoint which mutations influence the onset and progression of disease. Toward this goal, we describe a method called PARADIGMSHIFT that can predict whether a mutational event is neut

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