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Open Access Publications from the University of California

Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.

  • Author(s): Panagopoulou, Paraskevi
  • Skalkidou, Alkistis
  • Marcotte, Erin
  • Erdmann, Friederike
  • Ma, Xiaomei
  • Heck, Julia E
  • Auvinen, Anssi
  • Mueller, Beth A
  • Spector, Logan G
  • Roman, Eve
  • Metayer, Catherine
  • Magnani, Corrado
  • Pombo-de-Oliveira, Maria S
  • Scheurer, Michael E
  • Mora, Ana-Maria
  • Dockerty, John D
  • Hansen, Johnni
  • Kang, Alice Y
  • Wang, Rong
  • Doody, David R
  • Kane, Eleanor
  • Schüz, Joachim
  • Christodoulakis, Christos
  • Ntzani, Evangelia
  • Petridou, Eleni Th
  • FRECCLE group
  • NARECHEM-ST group
  • et al.

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BACKGROUND:Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent. AIM:To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. MATERIAL/METHODS:We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period. RESULTS:Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year. CONCLUSIONS:An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.

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This item is under embargo until September 29, 2021.