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Open Access Publications from the University of California

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.

  • Author(s): Ashworth, Alan
  • Rajan, N
  • Elliott, RJR
  • Smith, A
  • Sinclair, N
  • Swift, S
  • Lord, CJ
  • et al.

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CYLD, an ubiquitin hydrolase, has an expanding repertoire of regulatory roles in cell signalling and is dysregulated in a number of cancers. To dissect CYLD function we used a proteomics approach to identify CYLD interacting proteins and identified MIB2, a

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