Skip to main content
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
Published Web Location
https://doi.org/10.1038/ni.1725Abstract
The cytidine deaminase AID is required for antibody gene diversification. Casali and colleagues show that the transcription factor HoxC4 is expressed in germinal centers and is required for AID expression.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.