Skip to main content
Download PDF
- Main
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
- Kuchenbaecker, Karoline B;
- Ramus, Susan J;
- Tyrer, Jonathan;
- Lee, Andrew;
- Shen, Howard C;
- Beesley, Jonathan;
- Lawrenson, Kate;
- McGuffog, Lesley;
- Healey, Sue;
- Lee, Janet M;
- Spindler, Tassja J;
- Lin, Yvonne G;
- Pejovic, Tanja;
- Bean, Yukie;
- Li, Qiyuan;
- Coetzee, Simon;
- Hazelett, Dennis;
- Miron, Alexander;
- Southey, Melissa;
- Terry, Mary Beth;
- Goldgar, David E;
- Buys, Saundra S;
- Janavicius, Ramunas;
- Dorfling, Cecilia M;
- van Rensburg, Elizabeth J;
- Neuhausen, Susan L;
- Ding, Yuan Chun;
- Hansen, Thomas VO;
- Jønson, Lars;
- Gerdes, Anne-Marie;
- Ejlertsen, Bent;
- Barrowdale, Daniel;
- Dennis, Joe;
- Benitez, Javier;
- Osorio, Ana;
- Garcia, Maria Jose;
- Komenaka, Ian;
- Weitzel, Jeffrey N;
- Ganschow, Pamela;
- Peterlongo, Paolo;
- Bernard, Loris;
- Viel, Alessandra;
- Bonanni, Bernardo;
- Peissel, Bernard;
- Manoukian, Siranoush;
- Radice, Paolo;
- Papi, Laura;
- Ottini, Laura;
- Fostira, Florentia;
- Konstantopoulou, Irene;
- Garber, Judy;
- Frost, Debra;
- Perkins, Jo;
- Platte, Radka;
- Ellis, Steve;
- EMBRACE;
- Godwin, Andrew K;
- Schmutzler, Rita Katharina;
- Meindl, Alfons;
- Engel, Christoph;
- Sutter, Christian;
- Sinilnikova, Olga M;
- GEMO Study Collaborators;
- Damiola, Francesca;
- Mazoyer, Sylvie;
- Stoppa-Lyonnet, Dominique;
- Claes, Kathleen;
- De Leeneer, Kim;
- Kirk, Judy;
- Rodriguez, Gustavo C;
- Piedmonte, Marion;
- O'Malley, David M;
- de la Hoya, Miguel;
- Caldes, Trinidad;
- Aittomäki, Kristiina;
- Nevanlinna, Heli;
- Collée, J Margriet;
- Rookus, Matti A;
- Oosterwijk, Jan C;
- Breast Cancer Family Registry;
- Tihomirova, Laima;
- Tung, Nadine;
- Hamann, Ute;
- Isaccs, Claudine;
- Tischkowitz, Marc;
- Imyanitov, Evgeny N;
- Caligo, Maria A;
- Campbell, Ian G;
- Hogervorst, Frans BL;
- HEBON;
- Olah, Edith;
- Diez, Orland;
- Blanco, Ignacio;
- Brunet, Joan;
- Lazaro, Conxi;
- Pujana, Miquel Angel;
- Jakubowska, Anna;
- Gronwald, Jacek;
- Lubinski, Jan;
- Sukiennicki, Grzegorz;
- Barkardottir, Rosa B;
- Plante, Marie;
- Simard, Jacques;
- Soucy, Penny;
- Montagna, Marco;
- Tognazzo, Silvia;
- Teixeira, Manuel R;
- KConFab Investigators;
- Pankratz, Vernon S;
- Wang, Xianshu;
- Lindor, Noralane;
- Szabo, Csilla I;
- Kauff, Noah;
- Vijai, Joseph;
- Aghajanian, Carol A;
- Pfeiler, Georg;
- Berger, Andreas;
- Singer, Christian F;
- Tea, Muy-Kheng;
- Phelan, Catherine M;
- Greene, Mark H;
- Mai, Phuong L;
- Rennert, Gad;
- Mulligan, Anna Marie;
- Tchatchou, Sandrine;
- Andrulis, Irene L;
- Glendon, Gord;
- Toland, Amanda Ewart;
- Jensen, Uffe Birk;
- Kruse, Torben A;
- Thomassen, Mads;
- Bojesen, Anders;
- Zidan, Jamal;
- Friedman, Eitan;
- Laitman, Yael;
- Soller, Maria;
- Liljegren, Annelie;
- Arver, Brita;
- Einbeigi, Zakaria;
- Stenmark-Askmalm, Marie;
- Olopade, Olufunmilayo I;
- Nussbaum, Robert L;
- Rebbeck, Timothy R;
- Nathanson, Katherine L;
- Domchek, Susan M;
- Lu, Karen H;
- Karlan, Beth Y;
- Walsh, Christine;
- Lester, Jenny;
- Australian Cancer Study (Ovarian Cancer Investigators);
- Australian Ovarian Cancer Study Group;
- Hein, Alexander;
- Ekici, Arif B;
- Beckmann, Matthias W;
- Fasching, Peter A;
- Lambrechts, Diether;
- Van Nieuwenhuysen, Els;
- Vergote, Ignace;
- Lambrechts, Sandrina;
- Dicks, Ed;
- Doherty, Jennifer A;
- Wicklund, Kristine G;
- Rossing, Mary Anne;
- Rudolph, Anja;
- Chang-Claude, Jenny;
- Wang-Gohrke, Shan;
- Eilber, Ursula;
- Moysich, Kirsten B;
- Odunsi, Kunle;
- Sucheston, Lara;
- Lele, Shashi;
- Wilkens, Lynne R;
- Goodman, Marc T;
- Thompson, Pamela J;
- Shvetsov, Yurii B;
- Runnebaum, Ingo B;
- Dürst, Matthias;
- Hillemanns, Peter;
- Dörk, Thilo;
- Antonenkova, Natalia;
- Bogdanova, Natalia;
- Leminen, Arto;
- Pelttari, Liisa M;
- Butzow, Ralf;
- Modugno, Francesmary;
- Kelley, Joseph L;
- Edwards, Robert P;
- Ness, Roberta B;
- du Bois, Andreas;
- Heitz, Florian;
- Schwaab, Ira;
- Harter, Philipp;
- Matsuo, Keitaro;
- Hosono, Satoyo;
- Orsulic, Sandra;
- Jensen, Allan;
- Kjaer, Susanne Kruger;
- Hogdall, Estrid;
- Hasmad, Hanis Nazihah;
- Azmi, Mat Adenan Noor;
- Teo, Soo-Hwang;
- Woo, Yin-Ling;
- Fridley, Brooke L;
- Goode, Ellen L;
- Cunningham, Julie M;
- Vierkant, Robert A;
- Bruinsma, Fiona;
- Giles, Graham G;
- Liang, Dong;
- Hildebrandt, Michelle AT;
- Wu, Xifeng;
- Levine, Douglas A;
- Bisogna, Maria;
- Berchuck, Andrew;
- Iversen, Edwin S;
- Schildkraut, Joellen M;
- Concannon, Patrick;
- Weber, Rachel Palmieri;
- Cramer, Daniel W;
- Terry, Kathryn L;
- Poole, Elizabeth M;
- Tworoger, Shelley S;
- Bandera, Elisa V;
- Orlow, Irene;
- Olson, Sara H;
- Krakstad, Camilla;
- Salvesen, Helga B;
- Tangen, Ingvild L;
- Bjorge, Line;
- van Altena, Anne M;
- Aben, Katja KH;
- Kiemeney, Lambertus A;
- Massuger, Leon FAG;
- Kellar, Melissa;
- Brooks-Wilson, Angela;
- Kelemen, Linda E;
- Cook, Linda S;
- Le, Nhu D;
- Cybulski, Cezary;
- Yang, Hannah;
- Lissowska, Jolanta;
- Brinton, Louise A;
- Wentzensen, Nicolas;
- Hogdall, Claus;
- Lundvall, Lene;
- Nedergaard, Lotte;
- Baker, Helen;
- Song, Honglin;
- Eccles, Diana;
- McNeish, Ian;
- Paul, James;
- Carty, Karen;
- Siddiqui, Nadeem;
- Glasspool, Rosalind;
- Whittemore, Alice S;
- Rothstein, Joseph H;
- McGuire, Valerie;
- Sieh, Weiva;
- Ji, Bu-Tian;
- Zheng, Wei;
- Shu, Xiao-Ou;
- Gao, Yu-Tang;
- Rosen, Barry;
- Risch, Harvey A;
- McLaughlin, John R;
- Narod, Steven A;
- Monteiro, Alvaro N;
- Chen, Ann;
- Lin, Hui-Yi;
- Permuth-Wey, Jenny;
- Sellers, Thomas A;
- Tsai, Ya-Yu;
- Chen, Zhihua;
- Ziogas, Argyrios;
- Anton-Culver, Hoda;
- Gentry-Maharaj, Aleksandra;
- Menon, Usha;
- Harrington, Patricia;
- Lee, Alice W;
- Wu, Anna H;
- Pearce, Celeste L;
- Coetzee, Gerry;
- Pike, Malcolm C;
- Dansonka-Mieszkowska, Agnieszka;
- Timorek, Agnieszka;
- Rzepecka, Iwona K;
- Kupryjanczyk, Jolanta;
- Freedman, Matt;
- Noushmehr, Houtan;
- Easton, Douglas F;
- Offit, Kenneth;
- Couch, Fergus J;
- Gayther, Simon;
- Pharoah, Paul P;
- Antoniou, Antonis C;
- Chenevix-Trench, Georgia;
- Consortium of Investigators of Modifiers of BRCA1 and BRCA2
- et al.
Published Web Location
https://doi.org/10.1038/ng.3185Abstract
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%