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PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Published Web Location
https://doi.org/10.1038/nn.2603Abstract
The kinase mTOR functions to enhance cell growth in many systems. This study finds that injury reduces mTOR activity in neurons of the corticospinal tract (CST) and that enhancing mTOR activity by inactivation of its negative regulator PTEN substantially increases sprouting and regenerative growth of injured CST neurons.
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