Skip to main content
Open Access Publications from the University of California

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

  • Author(s): Makara, JK
  • Mor, M
  • Fegley, D
  • Szabó, SI
  • Kathuria, S
  • Astarita, G
  • Duranti, A
  • Tontini, A
  • Tarzia, G
  • Rivara, S
  • Freund, TF
  • Piomelli, D
  • et al.

Published Web Location Commons Attribution 4.0 International Public License

The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target. © 2005 Nature Publishing Group.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View