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Intimacy of the Niche: Perivascular Remodeling Cuddles Incoming HSCs
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https://doi.org/10.1016/j.stem.2015.01.011Abstract
Stem cells reside in "niches," which provide signaling cues necessary for self-renewal. In a recent issue of Cell, Tamplin et al. (2015) perform live imaging of hematopoietic stem and progenitor cells (HSPCs) and find dynamic remodeling of endothelial cells is triggered upon arrival of HSPCs at the caudal hematopoietic tissue.
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