UC San Diego

Purpose

To demonstrate the feasibility of a new method for measuring T₁ of short T₂ species based on an adiabatic inversion recovery-prepared three-dimensional ultrashort echo time Cones (3D IR-UTE-Cones) sequence.

Methods

T₁ values for short T₂ species were quantified using 3D IR-UTE-Cones data acquired with different repetition times (TRs) and inversion times (TIs). An inversion efficiency factor Q was introduced into the fitting model to accurately calculate T₁ values for short T₂ species. Experiments were performed on twelve MnCl₂ aqueous solution phantoms with a wide range of T₁ values and T₂* values on a 3 T clinical MR system to verify the efficacy of the proposed method. For comparison, a variable flip angle UTE (VFA-UTE) sequence, a variable TR UTE (VTR-UTE) sequence, and a conventional 2D IR fast spin echo (IR-FSE) sequence were also used to quantify T₁ values of those phantoms. T₁ values were compared between all performed sequences.

Results

The proposed 3D IR-UTE-Cones method provided higher contrast images of short T₂ phantoms and measured much shorter T₁ values than the VFA-UTE, VTR-UTE and 2D IR-FSE methods. T₁ values as short as 2.95 ms could be measured by the 3D IR-UTE-Cones sequence. The 3D IR-UTE-Cones methods with different TRs were applied to different ranges of T₁ measurement, and the scan time was significantly decreased by using 5 TIs along the recovery curves to perform fitting with comparable accuracy.

Conclusion

The 3D IR-UTE-Cones sequence could accurately measure short T₁ values while providing high contrast images of short T₂ species.