Skip to main content
Download PDF
- Main
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
- Lim, Ryan G;
- Salazar, Lisa L;
- Wilton, Daniel K;
- King, Alvin R;
- Stocksdale, Jennifer T;
- Sharifabad, Delaram;
- Lau, Alice L;
- Stevens, Beth;
- Reidling, Jack C;
- Winokur, Sara T;
- Casale, Malcolm S;
- Thompson, Leslie M;
- Pardo, Mónica;
- Díaz-Barriga, A Gerardo García;
- Straccia, Marco;
- Sanders, Phil;
- Alberch, Jordi;
- Canals, Josep M;
- Kaye, Julia A;
- Dunlap, Mariah;
- Jo, Lisa;
- May, Hanna;
- Mount, Elliot;
- Anderson-Bergman, Cliff;
- Haston, Kelly;
- Finkbeiner, Steven;
- Kedaigle, Amanda J;
- Gipson, Theresa A;
- Yildirim, Ferah;
- Ng, Christopher W;
- Milani, Pamela;
- Housman, David E;
- Fraenkel, Ernest;
- Allen, Nicholas D;
- Kemp, Paul J;
- Atwal, Ranjit Singh;
- Biagioli, Marta;
- Gusella, James F;
- MacDonald, Marcy E;
- Akimov, Sergey S;
- Arbez, Nicolas;
- Stewart, Jacqueline;
- Ross, Christopher A;
- Mattis, Virginia B;
- Tom, Colton M;
- Ornelas, Loren;
- Sahabian, Anais;
- Lenaeus, Lindsay;
- Mandefro, Berhan;
- Sareen, Dhruv;
- Svendsen, Clive N
Published Web Location
https://www.nature.com/neuro/journal/v20/n5/full/nn.4532.htmlAbstract
The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems biology to discover underlying mechanisms in HD. They identify neurodevelopmental deficits in HD cells that can be corrected in cells and in vivo with a small molecule.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.