- Main
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria
- Zee, Tiffany;
- Bose, Neelanjan;
- Zee, Jarcy;
- Beck, Jennifer N;
- Yang, See;
- Parihar, Jaspreet;
- Yang, Min;
- Damodar, Sruthi;
- Hall, David;
- O'Leary, Monique N;
- Ramanathan, Arvind;
- Gerona, Roy R;
- Killilea, David W;
- Chi, Thomas;
- Tischfield, Jay;
- Sahota, Amrik;
- Kahn, Arnold;
- Stoller, Marshall L;
- Kapahi, Pankaj
Published Web Location
https://doi.org/10.1038/nm.4280Abstract
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-