UCLA

Blunted neural responses to reward in an EEG paradigm (RewP) are associated with vulnerability to depression, but the pathways linking this biomarker to depressive symptoms are unclear. We examined whether the relationship between reward response (RewP mean amplitude and latency) and depression was in part explained by approach-motivated behaviors in adolescents with varying levels of depression. EEG was collected during a game rigged to provide win/loss trials. Longer RewP latency was associated with depression symptoms only when scores on a measure of avoidance motivation were included. These results suggest that treatments targeting avoidance may decrease vulnerability to depressive episodes.