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Association of Chronic Cough and Pulmonary Function With 6-Minute Walk Test Performance in HIV Infection
Published Web Location
http://ovidsp.tx.ovid.com/sp-3.23.0a/ovidweb.cgi?WebLinkFrameset=1&S=BCAMFPFOANDDILMPNCHKJBDCDMGLAA00&returnUrl=ovidweb.cgi?&Full+Text=L%257cS.sh.22.23%257c0%257c00126334-201404150-00008&S=BCAMFPFOANDDILMPNCHKJBDCDMGLAA00&directlink=http://ovidsp.tx.ovid.com/ovftpdfs/FPDDNCDCJBMPAN00/fs047/ovft/live/gv024/00126334/00126334-201404150-00008.pdf&filename=Association+of+Chronic+Cough+and+Pulmonary+Function+With+6-Minute+Walk+Test+Performance+in+HIV+Infection.&pdf_key=FPDDNCDCJBMPAN00&pdf_index=/fs04No data is associated with this publication.
Abstract
Objective
Chronic lung disease has been associated with greater impairment in self-reported physical function in HIV-infected patients. We sought to study this association using objective measures of physical function and pulmonary function.Design
Baseline data from the Examinations of HIV Associated Lung Emphysema study, a multicenter observational cohort of HIV-infected and uninfected veterans.Methods
We assessed the association between clinical, laboratory, and pulmonary function measures with 6-minute walk test (6-MWT). Multivariable linear regression models were generated to identify factors associated with 6-MWT performance.Results
Three hundred forty participants completed 6-MWT (mean age 55 years), with 68% blacks, 94% men, and 62% current smokers. Overall, 180 (53%) were HIV-infected and 63 (19%) had spirometry-defined chronic obstructive pulmonary disease. In a multivariable model, age, current smoking, and obesity (body mass index > 30) were independently associated with lower 6-MWT performance, but HIV infection was not; there was a significant interaction between HIV and chronic cough, such that distance walked among HIV-infected participants with chronic cough was 51.76 m less (P = 0.04) compared with those without cough or HIV. Among HIV-infected participants, the forced expiratory volume in 1 second (FEV1, percent predicted), to a greater extent than total lung capacity or diffusing capacity, attenuated the association with chronic cough; decreased FEV1 was independently associated with lower 6-MWT performance in those with HIV.Conclusions
Older age, current smoking, and airflow limitation were important determinants of 6-MWT performance in the HIV-infected participants. These findings suggest that potential interventions to improve physical function may include early management of respiratory symptoms and airflow limitation.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.