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Development of an in vivo model for the study of photodynamic therapy and anti-angiogenic treatments
Abstract
An in vivo model has been developed for the study of photodynamic therapy (PDT) and anti-angiogenic treatments. Significant damage to the vasculature of the chick chorioallantoic membrane (CAM) was observed immediately following PDT with 5-aminolevulinic acid (ALA). Multicell human glioma spheroids were placed on the CAM at day five of embryonic development, however, neovascularization was not observed.
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