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An inflammatory switch for stem cell plasticity
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https://doi.org/10.1038/s41556-021-00752-4Abstract
Tissue resident stem cells are capable of remarkable plasticity in areas of tissue damage, where inflammatory cells accumulate as part of the reparative response. A study in the lung now provides critical insight on how inflammatory signals alter cell-to-cell Notch signaling within the airway niche to drive stem cell plasticity.
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