Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling.
- Author(s): Nawrat, Christopher C;
- Jamison, Christopher R;
- Slutskyy, Yuriy;
- MacMillan, David WC;
- Overman, Larry E
- et al.
Published Web Locationhttps://doi.org/10.1021/jacs.5b07678
Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient alkenes is achieved.