Skip to main content
eScholarship
Open Access Publications from the University of California

Temporospatial components of brain ERPs as biomarkers for Alzheimer's disease.

  • Author(s): Chapman, Robert M
  • Gardner, Margaret N
  • Klorman, Rafael
  • Mapstone, Mark
  • Porsteinsson, Anton P
  • Antonsdottir, Inga M
  • Kamalyan, Lily
  • et al.
Abstract

Introduction:Developing biomarkers that distinguish individuals with Alzheimer's disease (AD) from those with normal cognition remains a crucial goal for improving the health of older adults. We investigated adding brain spatial information to temporal event-related potentials (ERPs) to increase AD identification accuracy over temporal ERPs alone. Methods:With two-step principal components analysis, we applied multivariate analyses that incorporated temporal and spatial ERP information from a cognitive task. Discriminant analysis used temporospatial ERP scores to classify participants as belonging to either the AD or healthy control group. Results:Temporospatial ERPs produced a cross-validated area under the curve of 0.84. Adding spatial information through a formal procedure significantly improves classification accuracy. Discussion:A weighted combination of temporospatial ERP markers performs well in detecting AD. Because ERPs are noninvasive and inexpensive, they may be promising biomarkers for AD that can add functional information to other biomarker systems while providing the individual's probability of correct classification.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View