Cognitive Impairment and Risk Factors of LATE, a Novel Degenerative Pathology
Skip to main content
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Cognitive Impairment and Risk Factors of LATE, a Novel Degenerative Pathology

Published Web Location Commons 'BY' version 4.0 license

Background: Limbic predominant age related TDP-43 encephalopathy (LATE) is a newly proposed term to denote the contribution of transactive response DNA-binding pro-tein of 43 kDa (TDP-43) pathology to dementia at older age. The aim of this work was to study the role of LATE in cognitive impairment and its risk factors in the oldest old (those ≥ 90years old). Methods: 240 participants of The 90+ Study with comprehensive clinical, neuropsychology, and neuropathology data were included. Dementia status, clinical syndrome, and impaired cognitive domains were determined at multidisciplinary post-mortem case conferences blind to autopsy data. Alzheimer’s disease neuropathology (ADNP) was defined as CERAD neuritic plaque score≥2 and Braak neuro-fibrillary tangle stage≥5. We defined LATE as those with at least amygdala and hippocampal TDP-43 pathology (stage>2). We explored the association of LATE and of ADNP with cognition measures by logistic regression ana-lyses adjusting for age, sex, and education. We separately explored the association between medical histories (as potential risk factors) and LATE and ADNP as outcomes adjusting for the above covariates.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View