Isolation and characterization of a light chain variable region gene for human rheumatoid factors.
- Author(s): Chen, PP
- Robbins, DL
- Jirik, FR
- Kipps, TJ
- Carson, DA
- et al.
Published Web Locationhttps://doi.org/10.1084/jem.166.6.1900
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.