Skip to main content
eScholarship
Open Access Publications from the University of California

Isolation and characterization of a light chain variable region gene for human rheumatoid factors.

  • Author(s): Chen, PP
  • Robbins, DL
  • Jirik, FR
  • Kipps, TJ
  • Carson, DA
  • et al.
Abstract

Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View