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Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

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http://europepmc.org/articles/PMC4436593?pdf=render
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Abstract

© 2015, eLife Sciences Publications Ltd. All rights reserved.Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conve

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