Skip to main content
Open Access Publications from the University of California

Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

  • Author(s): Goetzl, Edward J
  • Boxer, Adam
  • Schwartz, Janice B
  • Abner, Erin L
  • Petersen, Ronald C
  • Miller, Bruce L
  • Carlson, Olga D
  • Mustapic, Maja
  • Kapogiannis, Dimitrios
  • et al.

Published Web Location

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View