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Low neural exosomal levels of cellular survival factors in Alzheimer's disease

  • Author(s): Goetzl, EJ
  • Boxer, A
  • Schwartz, JB
  • Abner, EL
  • Petersen, RC
  • Miller, BL
  • Carlson, OD
  • Mustapic, M
  • Kapogiannis, D
  • et al.

Published Web Location

https://doi.org/10.1002/acn3.211
Abstract

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

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