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Conformational biosensors reveal GPCR signalling from endosomes
- Irannejad, Roshanak;
- Tomshine, Jin C;
- Tomshine, Jon R;
- Chevalier, Michael;
- Mahoney, Jacob P;
- Steyaert, Jan;
- Rasmussen, Søren GF;
- Sunahara, Roger K;
- El-Samad, Hana;
- Huang, Bo;
- von Zastrow, Mark
Published Web Location
https://doi.org/10.1038/nature12000Abstract
Conformation-specific antibodies capable of monitoring the activation state of a G-protein-coupled seven-transmembrane receptor, the β2-adrenoceptor, reveals receptor and G-protein activation not only in the plasma membrane, but also in the endosome.
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