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Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion
- Faber, Franziska;
- Tran, Lisa;
- Byndloss, Mariana X;
- Lopez, Christopher A;
- Velazquez, Eric M;
- Kerrinnes, Tobias;
- Nuccio, Sean-Paul;
- Wangdi, Tamding;
- Fiehn, Oliver;
- Tsolis, Renée M;
- Bäumler, Andreas J
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939260/No data is associated with this publication.
Abstract
Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.
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