A model of lysosomal pH regulation.
- Author(s): Grabe, Michael
- Ishida, Y
- Nayak, S
- Mindell, JA
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3664703?pdf=render
Lysosomes must maintain an acidic luminal pH to activate hydrolytic enzymes and degrade internalized macromolecules. Acidification requires the vacuolar-type H(+)-ATPase to pump protons into the lumen and a counterion flux to neutralize the membrane potent
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