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A model of lysosomal pH regulation.

  • Author(s): Grabe, Michael
  • Ishida, Y
  • Nayak, S
  • Mindell, JA
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3664703?pdf=render
No data is associated with this publication.
Abstract

Lysosomes must maintain an acidic luminal pH to activate hydrolytic enzymes and degrade internalized macromolecules. Acidification requires the vacuolar-type H(+)-ATPase to pump protons into the lumen and a counterion flux to neutralize the membrane potent

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