UCSF

OBJECTIVE: To study the longitudinal changes of cartilage T 1 ρ and T 2 relaxation time measurements in hip-OA patients. METHODS: A calibration study compared two scanner data, Scanner-1 (GE Discovery MR750 3.0T) with unilateral acquisition protocol and Scanner-2 (GE Signa Premier 3.0T) with bilateral acquisition protocol, using nine subjects(average age ​= ​40.33 ​± ​13.53 years, 5 females), including one hip-OA subject. Quantified parameters from the Scanner-2 were adjusted using voxel-based relaxometry(VBR) and Z-score normalization to reduce the inter-scanner variability. Eighteen hip-OA Subjects (age ​= ​53.11 ​± ​14.96 years, 12 females) were recruited to the longitudinal variability study from 2016, comprising five assessments at 1-year intervals. Baseline to 3rd-year data used unilateral acquisition with Scanner-1, while 4th-year data used bilateral acquisition with Scanner-2. A linear mixed-effects model(LME) assessed trajectory analyses, with acquisition year, age, sex, body mass index(BMI), and Kellgren-Lawrence(KL) score as predictor variables and cartilage mean T 1 ρ and T 2 values as outcomes. RESULTS: VBR analysis after Z-score normalization showed that only a few of the whole cartilage voxels had significant differences in T 1 ρ ( femur-2.36 ​% and acetabular-3.23 ​%) and T 2 (femur-2.30 ​% and acetabular-2.94 ​%) values between the scanners. The LME analysis showed that the BMI predictor variable was significantly correlated with the femur T 1 ρ (p ​< ​0.0001) and T 2 (p ​< ​0.0001) and acetabular T 1 ρ (p ​< ​0.0001) and T 2 (p ​< ​0.0001) cartilage region. CONCLUSION: The calibration study demonstrated the effectiveness of VBR and Z-score normalization in reducing inter-scanner variability. The longitudinal study revealed a significant correlation between T 1 ρ and T 2 values of the cartilage and BMI; also the T 1 ρ and T 2 values increased over time in some of the cartilage subregions.