Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
- Author(s): Whipple, Chery A
- Lander, Arthur D
- Korc, Murray
- et al.
Published Web Locationhttps://doi.org/10.1100/tsw.2008.152
The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell-derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.