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Open Access Publications from the University of California

Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

  • Author(s): Whipple, Chery A
  • Lander, Arthur D
  • Korc, Murray
  • et al.
Abstract

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell-derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

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