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An inhibitory pull-push circuit in frontal cortex.

  • Author(s): Garcia-Junco-Clemente, Pablo;
  • Ikrar, Taruna;
  • Tring, Elaine;
  • Xu, Xiangmin;
  • Ringach, Dario L;
  • Trachtenberg, Joshua T
  • et al.

Published Web Location

https://doi.org/10.1038/nn.4483
Abstract

Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.

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