Skip to main content
Open Access Publications from the University of California


UCLA Previously Published Works bannerUCLA

An inhibitory pull-push circuit in frontal cortex.

  • Author(s): Garcia-Junco-Clemente, Pablo
  • Ikrar, Taruna
  • Tring, Elaine
  • Xu, Xiangmin
  • Ringach, Dario L
  • Trachtenberg, Joshua T
  • et al.

Published Web Location

Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View