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An inhibitory pull–push circuit in frontal cortex
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https://doi.org/10.1038/nn.4483Abstract
Using large-network calcium imaging in alert mouse frontal cortex, the authors identify a significant covariance of responses of VIP interneurons and pyramidal cells. Optogenetic interrogation of this brain region revealed a pull–push inhibitory circuit driven by neuromodulation of VIP interneurons that contrasts with canonical feedforward push–pull excitation.
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