An inhibitory pull-push circuit in frontal cortex.
- Author(s): Garcia-Junco-Clemente, Pablo;
- Ikrar, Taruna;
- Tring, Elaine;
- Xu, Xiangmin;
- Ringach, Dario L;
- Trachtenberg, Joshua T
- et al.
Published Web Locationhttps://doi.org/10.1038/nn.4483
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.