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Use of anticoagulants and antiplatelet in patients with chronic lymphocytic leukaemia treated with single-agent ibrutinib.

  • Author(s): Jones, Jeffrey A;
  • Hillmen, Peter;
  • Coutre, Steven;
  • Tam, Constantine;
  • Furman, Richard R;
  • Barr, Paul M;
  • Schuster, Stephen J;
  • Kipps, Thomas J;
  • Flinn, Ian W;
  • Jaeger, Ulrich;
  • Burger, Jan A;
  • Cheng, Mei;
  • Ninomoto, Joi;
  • James, Danelle F;
  • Byrd, John C;
  • O'Brien, Susan M
  • et al.

Published Web Location

https://doi.org/10.1111/bjh.14660Creative Commons 'BY' version 4.0 license
Abstract

Bleeding events have been observed among a subgroup of chronic lymphocytic leukaemia (CLL) patients treated with ibrutinib. We analysed data from two studies of single-agent ibrutinib to better characterize bleeding events and pattern of anticoagulation and antiplatelet use. Among 327 ibrutinib-treated patients, concomitant anticoagulation (11%) or antiplatelet use (34%) was common, but major bleeding was infrequent (2%). Bleeding events were primarily grade 1, and infrequently (1%) led to discontinuation. Among 175 patients receiving concomitant anticoagulant or antiplatelet agents, 5 had major bleeding events (3%). These events were typically observed in conjunction with other factors, such as coexisting medical conditions and/or concurrent medications.

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