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Unknown: Bilateral symmertrical papules on the eyelid

  • Author(s): Duarte, Ana F
  • Nogueira, Ana
  • Lisboa, Carmen
  • Azevedo, Filomena
  • et al.
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Unknown: Bilateral symmetrical papules on the eyelid
Ana F Duarte MD1,2, Ana Nogueira MD1, Carmen Lisboa MD1,2, Filomena Azevedo MD1
Dermatology Online Journal 15 (5): 13

1. Department of Dermatology and Venereology, Hospital de São João, Porto, Portugal. duarte.af.t30@gmail.com
2. Faculty of Medicine, Porto, Portugal



Case synopsis


Figure 1
Figure 1. Multiple bilateral symmetrical papules on the eyelids, slightly firm and yellow to tan and ranged from 2 to 6 mm in the long axis

A 46-year-old woman presented with a 5-year history of bilateral symmetrical papules on the upper and lower eyelids. The papules had progressively grown in number and dimension. Besides cosmetic concerns, the patient noted that the lesions were asymptomatic and she was otherwise healthy.

Physical examination revealed multiple bilateral symmetrical papules on the eyelids, slightly firm and yellow to tan, ranging from 2 to 6 mm in the long axis (Fig. 1). An incisional biopsy specimen was obtained (Figs. 2A & 2B).


Figure 2A Figure 2B
Figure 2A. Clear cell nests in the upper dermis, surrounded by fibrous stroma and amorphous material in the intraductal space (H&E, x40)

Figure 2B. PAS staining showed reactive spots in the cytoplasm and intraductal space

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