An unusual karyotype in leiomyoma: Case report and literature review.
- Author(s): Chang, Le
- Rao, Nagesh
- Bernthal, Nicholas
- Dry, Sarah M
- James, Aaron W
- et al.
Published Web Locationhttps://doi.org/10.1016/j.jor.2015.10.016
Vascular leiomyoma are uncommon, clinically benign smooth muscle tumors. Here we report a case of an otherwise typical leiomyoma with unusual cytogenetic changes including t(1;10). Reports from the existing literature suggest that approximately 40-50% of leiomyomas contain nonrandom chromosomal abnormalities of which a subset is tumor specific. t(12;14)(q15;q24) is one of the most common translocations, which occur in approximately 20% of karyotypes. Additional aberrations include del(7)(q22-q32), trisomy 12, and 6p21 rearrangements. Other recurrent abnormalities include monosomy 22, monosomy 10, del(10q), and structural rearrangements of chromosome 3.