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COMPRES: A prospective postmarketing evaluation of the compression anastomosis ring CAR 27/ColonRing

  • Author(s): D'Hoore, A
  • Albert, MR
  • Cohen, SM
  • Herbst, F
  • Matter, I
  • Van Der Speeten, K
  • Dominguez, J
  • Rutten, H
  • Muldoon, JP
  • Bardakcioglu, O
  • Senagore, AJ
  • Ruppert, R
  • Mills, S
  • Stamos, MJ
  • Påhlman, L
  • Choman, E
  • Wexner, SD
  • On behalf of the COMPRES collaborative study group
  • et al.
Abstract

© 2015 The Association of Coloproctology of Great Britain and Ireland 17 6 June 2015 10.1111/codi.12884 Original Article Original Articles General Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland. Aim: Preclinical studies have suggested that nitinol-based compression anastomosis might be a viable solution to anastomotic leak following low anterior resection. A prospective multicentre open label study was therefore designed to evaluate the performance of the ColonRing in (low) colorectal anastomosis. Method: The primary outcome measure was anastomotic leakage. Patients were recruited at 13 different colorectal surgical units in Europe, the United States and Israel. Institutional review board approval was obtained. Results: Between 21 March 2010 and 3 August 2011, 266 patients completed the study protocol. The overall anastomotic leakage rate was 5.3% for all anastomoses, including a rate of 3.1% for low anastomoses. Septic anastomotic complications occurred in 8.3% of all anastomoses and 8.2% of low anastomoses. Conclusion: Nitinol compression anastomosis is safe, effective and easy to use and may offer an advantage for low colorectal anastomosis. A prospective randomized trial comparing ColonRing with conventional stapling is needed. Copyright

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