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Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments

  • Author(s): Sali, Andrej
  • Gradišar, H
  • Božič, S
  • Doles, T
  • Vengust, D
  • Hafner-Bratkovič, I
  • Mertelj, A
  • Webb, B
  • Šali, A
  • Klavžar, S
  • Jerala, R
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3661711?pdf=render
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Abstract

Protein structures evolved through a complex interplay of cooperative interactions, and it is still very challenging to design new protein folds de novo. Here we present a strategy to design self-assembling polypeptide nanostructured polyhedra based on mod

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