Skip to main content
Open Access Publications from the University of California

Discovering human RNA aptamers by structure-based bioinformatics and genome-based in vitro selection.

  • Author(s): Ho, Bao
  • Polanco, Julio
  • Jimenez, Randi
  • Lupták, Andrej
  • Editor(s): Burke-Aguaro, D
  • et al.

In vitro selection and structure-based searches have emerged as useful techniques for the discoveries of structurally complex RNAs with high affinity and specificity toward metabolites. Here, we focus on the design of a human genomic library that serves as the DNA template for in vitro selection of RNA aptamers. In addition, the structural solutions obtained from the in vitro selection can be used for structure-based searches for discovery of analogous aptamers in various genomic databases.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View