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Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

Published Web Location

http://europepmc.org/articles/PMC4106236?pdf=render
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Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have distinct clinical features but a common pathology-cytoplasmic inclusions rich in transactive response element DNA-binding protein of 43 kDa (TDP43). Rare TDP43 mutations cause ALS o

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