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Amyloid in dementia associated with familial FTLD: not an innocent bystander

  • Author(s): Naasan, G
  • Rabinovici, GD
  • Ghosh, P
  • Elofson, JD
  • Miller, BL
  • Coppola, G
  • Karydas, A
  • Fong, J
  • Perry, D
  • Lee, SE
  • Yokoyama, JS
  • Seeley, WW
  • Kramer, JH
  • Weiner, MW
  • Schuff, N
  • Jagust, WJ
  • Grinberg, LT
  • Pribadi, M
  • Yang, Z
  • Sears, R
  • Klein, E
  • Wojta, K
  • Rosen, HJ
  • et al.
Abstract

© 2015 Taylor & Francis Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer’s disease-like pattern of neurodegeneration.

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