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Amyloid in dementia associated with familial FTLD: not an innocent bystander
- Naasan, Georges;
- Rabinovici, Gil D;
- Ghosh, Pia;
- Elofson, Jonathan D;
- Miller, Bruce L;
- Coppola, Giovanni;
- Karydas, Anna;
- Fong, Jamie;
- Perry, David;
- Lee, Suzee E;
- Yokoyama, Jennifer S;
- Seeley, William W;
- Kramer, Joel H;
- Weiner, Michael W;
- Schuff, Norbert;
- Jagust, William J;
- Grinberg, Lea T;
- Pribadi, Mochtar;
- Yang, Zhongan;
- Sears, Renee;
- Klein, Eric;
- Wojta, Kevin;
- Rosen, Howard J
- et al.
Published Web Location
https://doi.org/10.1080/13554794.2015.1046458Abstract
Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case-control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer's disease-like pattern of neurodegeneration.
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