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Open Access Publications from the University of California

Lost in translation: ambiguity in nerve sheath tumor nomenclature and its resultant treatment effect.

  • Author(s): Bernthal, Nicholas M
  • Jones, Kevin B
  • Monument, Michael J
  • Liu, Ting
  • Viskochil, David
  • Randall, R Lor
  • et al.

There is much ambiguity surrounding the diagnosis of nerve sheath tumors, including atypical neurofibroma and low-grade MPNST, and yet, the distinction between these entities designates either benign or malignant behavior and thus carries presumed profound prognostic importance that often guides treatment. This study reviews the diagnostic criteria used to designate atypical neurofibroma from low-grade MPNSTs and reviews existing literature the natural history of each of these tumors to see if the distinction is, in fact, of importance.

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