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Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
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https://doi.org/10.3390/bioengineering6020038Abstract
Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling.
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