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Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist
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https://doi.org/10.1111/bph.12810Abstract
Background and Purpose The opioid receptor family comprises four structurally homologous but functionally distinct sub-groups, the μ (MOP), δ (DOP), κ (KOP) and nociceptin (NOP) receptors. As most opioid agonists are selective but not specific, a broad spectrum of behaviours due to activation of different opioid receptors is expected. In this study, we examine whether other opioid receptor systems influenced KOP-mediated antinociception.
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