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Understanding brain penetrance of anticancer drugs
Published Web Location
https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noy018/4883182No data is associated with this publication.
Abstract
This paper explicates the impact of tumor capillary permeability for glioma World Health Organization (WHO) grades II to IV on brain-penetrant drug entry and distribution within the tumor and the brain adjacent to tumor (leading edge). In addition, we consider the distribution of non-brain penetrant drugs and how, in some cases, large-molecular-weight drugs might achieve good distribution into tumor and brain adjacent to tumor.
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