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Risk of Parkinson's disease dementia related to level I MDS PD-MCI.

  • Author(s): Hoogland, Jeroen
  • Boel, Judith A
  • de Bie, Rob MA
  • Schmand, Ben A
  • Geskus, Ronald B
  • Dalrymple-Alford, John C
  • Marras, Connie
  • Adler, Charles H
  • Weintraub, Daniel
  • Junque, Carmen
  • Pedersen, Kenn F
  • Mollenhauer, Brit
  • Goldman, Jennifer G
  • Tröster, Alexander I
  • Burn, David J
  • Litvan, Irene
  • Geurtsen, Gert J
  • MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pubmed/30653248
No data is associated with this publication.
Abstract

BACKGROUND:The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. METHODS:We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. RESULTS:Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. CONCLUSIONS:Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.

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