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Baseline sputum eosinophil + neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort
- Hastie, Annette T;
- Mauger, David T;
- Denlinger, Loren C;
- Coverstone, Andrea;
- Castro, Mario;
- Erzurum, Serpil;
- Jarjour, Nijar;
- Levy, Bruce D;
- Meyers, Deborah A;
- Moore, Wendy C;
- Phillips, Brenda;
- Wenzel, Sally E;
- Fahy, John V;
- Israel, Elliot;
- Bleecker, Eugene R;
- Investigators, NHLBI SARP 3;
- Crosby-Thompson, Allison;
- Nettles, Carrie;
- Cinelli, Angeles;
- Le, Meghan;
- Lawrence, Joy;
- Liu, Donna;
- Mock, Jenelle;
- Klaus, Danica;
- Crisafi, Gina;
- Smith, Regina;
- Krings, Jeff;
- Weaver, Rachel;
- Nguyen, Daniel;
- McIntire, Kristin;
- Baicker-McKee, Sara;
- Charbit, Annabelle;
- Trudeau, John;
- Floerke, Heather;
- Foster, Susan;
- Rector, Brian;
- Yin-Declue, Huiqing;
- Noel, Patricia;
- Croxton, Tom;
- Smith, Robert
- et al.
Published Web Location
https://doi.org/10.1016/j.jaci.2020.01.039Abstract
Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect.
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