Astrocytes Underlie Neuroinflammatory Memory Impairment.
- Author(s): Osso, Lindsay A
- Chan, Jonah R
- et al.
Published Web Locationhttps://doi.org/10.1016/j.cell.2015.12.001
Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.