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Open Access Publications from the University of California

Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

  • Author(s): McKerrow, James
  • Leung, Jacqueline
  • McCune, Joseph
  • Broadhurst, MJ
  • Leung, JM
  • Lim, KC
  • Girgis, NM
  • Gundra, UM
  • Fallon, PG
  • Premenko-Lanier, M
  • McKerrow, JH
  • McCune, JM
  • Loke, P
  • et al.

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Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a ret

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