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Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.
- Maylott, Sarah;
- Conradt, Elisabeth;
- McGrath, Monica;
- Knapp, Emily;
- Li, Xiuhong;
- Musci, Rashelle;
- Aschner, Judy;
- Avalos, Lyndsay;
- Croen, Lisa;
- Deoni, Sean;
- Derefinko, Karen;
- Elliott, Amy;
- Hofheimer, Julie;
- Leve, Leslie;
- Madan, Juliette;
- Mansolf, Maxwell;
- Murrison, Liza;
- Neiderhiser, Jenae;
- Ozonoff, Sally;
- Posner, Jonathan;
- Salisbury, Amy;
- Sathyanarayana, Sheela;
- Schweitzer, Julie;
- Seashore, Carl;
- Stabler, Meagan;
- Young, Leslie;
- Ondersma, Steven;
- Lester, Barry
- et al.
Published Web Location
https://doi.org/10.1016/j.jpeds.2023.113468Abstract
OBJECTIVES: To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use. STUDY DESIGN: As part of the Environmental influences on Child Health Outcomes Program, we harmonized prenatal substance use data and child behavior outcomes from 2195 women and their 6- to 11-year-old children across 10 cohorts in the US and used latent class-adjusted regression models to predict parent-rated child behavior. RESULTS: Three latent classes fit the data: low use (90.5%; n = 1986), primarily using no substances; licit use (6.6%; n = 145), mainly using nicotine with a moderate likelihood of using alcohol and marijuana; and illicit use (2.9%; n = 64), predominantly using illicit substances along with a moderate likelihood of using licit substances. Children exposed to primarily licit substances in utero had greater levels of externalizing behavior than children exposed to low or no substances (P = .001, d = .64). Children exposed to illicit substances in utero showed small but significant elevations in internalizing behavior than children exposed to low or no substances (P < .001, d = .16). CONCLUSIONS: The differences in prenatal polysubstance use may increase risk for specific childhood problem behaviors; however, child outcomes appeared comparably adverse for both licit and illicit polysubstance exposure. We highlight the need for similar multicohort, large-scale studies to examine childhood outcomes based on prenatal substance use profiles.
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