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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation
- Hoffmann, Thomas J;
- Ehret, Georg B;
- Nandakumar, Priyanka;
- Ranatunga, Dilrini;
- Schaefer, Catherine;
- Kwok, Pui-Yan;
- Iribarren, Carlos;
- Chakravarti, Aravinda;
- Risch, Neil
Published Web Location
https://doi.org/10.1038/ng.3715Abstract
Thomas Hoffmann, Neil Risch and colleagues use longitudinal electronic health records from almost 100,000 individuals to conduct genome-wide association studies for blood pressure measurements. They find new significant loci that replicate in independent cohorts and can double the variance explained by using multiple blood pressure data points.
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