Diels-Alder construction of regiodifferentiated meta-amino phenols and derivatives.
- Author(s): Weaver, Marisa G
- Bai, Wen-Ju
- Jackson, Stephen K
- Pettus, Thomas RR
- et al.
Published Web Locationhttps://doi.org/10.1021/ol4034447
Synthetic access to regiodifferentiated meta-amino phenols is described. The strategy relies upon distinct deprotonation conditions to afford regioisomeric thermodynamic and kinetic dienes that undergo a tandem Diels-Alder and retro-Diels-Alder sequence with assorted acetylenic dienophiles to afford a range of aromatic products.