A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo.
- Author(s): Somayaji, Mahalakshmi;
- Cataldi, Stefano;
- Choi, Se Joon;
- Edwards, Robert H;
- Mosharov, Eugene V;
- Sulzer, David
- et al.
Published Web Locationhttps://doi.org/10.1073/pnas.2013652117
α-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the regulation of neurotransmission under physiologically relevant conditions has proven elusive. We report that, in vivo, α-synuclein is responsible for the facilitation of dopamine release triggered by action potential bursts separated by short intervals (seconds) and a depression of release with longer intervals between bursts (minutes). These forms of presynaptic plasticity appear to be independent of the presence of β- and γ-synucleins or effects on presynaptic calcium and are consistent with a role for synucleins in the enhancement of synaptic vesicle fusion and turnover. These results indicate that the presynaptic effects of α-synuclein depend on specific patterns of neuronal activity.