Research Grants Program Office (RGPO)
A Biomimetic Synthesis of des-Hydroxy Paecilospirone
- Author(s): Feng, Zhen-Gao
- Burnett, G Leslie
- Pettus, Thomas RR
- et al.
Published Web Locationhttps://doi.org/10.1055/s-0036-1592001
The carbon framework of des-hydroxy paecilospirone was rapidly synthesized using a biomimetic approach whereby an enol ether and an ortho-quinone methide (o-QM), each derived from the same lactone, were combined to arrive at the complete carbon skeleton of paecilospirone.