Photoradiation therapy of gynecologic malignancies.
- Author(s): Rettenmaier, MA
- Berman, ML
- DiSaia, PJ
- Burns, RG
- Berns, MW
- et al.
Published Web Locationhttps://doi.org/10.1016/0090-8258(84)90078-7
Four patients with gynecologic tumors recurrent either to the vagina or skin were treated with photoradiation therapy. A cytotoxic effect on the tumor was achieved by injecting hematoporphyrin derivative intravenously followed by exposing the treatment area to light of 630 nm from an argon-ion pumped-dye laser 72 hr later. Of seven tumor sites which were treated, one was completely destroyed, two were diminished in volume by more than 30%, and no response was seen in four. Toxicity was limited to one episode of facial edema and first-degree burn after prolonged exposure to bright artificial light. Phototherapy might be a useful treatment of some gynecologic tumors which recur after standard attempts at control of disease.