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Angiotensin-converting enzyme inhibitor use and incident frailty in women aged 65 and older: prospective findings from the Women's Health Initiative Observational Study.
- Author(s): Gray, Shelly L;
- LaCroix, Andrea Z;
- Aragaki, Aaron K;
- McDermott, Mary;
- Cochrane, Barbara B;
- Kooperberg, Charles L;
- Murray, Anne M;
- Rodriguez, Beatriz;
- Black, Henry;
- Woods, Nancy F;
- Women's Health Initiative Observational Study
- et al.
Published Web Locationhttp://10.0.4.87/j.1532-5415.2008.02121.x
No data is associated with this publication.
ObjectivesTo examine the associations between current use, duration, and potency of angiotensin-converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline.
DesignData were from the Women's Health Initiative Observational Study (WHI-OS), a prospective study conducted at 40 U.S. clinical centers.
ParticipantsWomen aged 65 to 79 at baseline who were not frail (N=27,378).
MeasurementsCurrent ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self-reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self-reported and physical measurements data at baseline and 3-year clinic contacts.
ResultsBy the 3-year follow-up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82-1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension.
ConclusionOverall, incidence of frailty was similar in current ACE inhibitor users and nonusers.
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